diff --git a/addons/web/static/src/js/components/dropdown_menu.js b/addons/web/static/src/js/components/dropdown_menu.js
index c536f3caba7..64c30b6500e 100644
--- a/addons/web/static/src/js/components/dropdown_menu.js
+++ b/addons/web/static/src/js/components/dropdown_menu.js
@@ -121,7 +121,11 @@ odoo.define('web.DropdownMenu', function (require) {
          * @param {MouseEvent} ev
          */
         _onWindowClick(ev) {
-            if (this.state.open && !this.el.contains(ev.target)) {
+            if (
+                this.state.open &&
+                !this.el.contains(ev.target) &&
+                !this.el.contains(document.activeElement)
+            ) {
                 this.state.open = false;
             }
         }
diff --git a/addons/web/static/src/js/components/dropdown_menu_item.js b/addons/web/static/src/js/components/dropdown_menu_item.js
index bc028e17719..bcc54ab4ffb 100644
--- a/addons/web/static/src/js/components/dropdown_menu_item.js
+++ b/addons/web/static/src/js/components/dropdown_menu_item.js
@@ -86,7 +86,11 @@ odoo.define('web.DropdownMenuItem', function (require) {
          * @param {MouseEvent} ev
          */
         _onWindowClick(ev) {
-            if (this.state.open && !this.el.contains(ev.target)) {
+            if (
+                this.state.open &&
+                !this.el.contains(ev.target) &&
+                !this.el.contains(document.activeElement)
+            ) {
                 this.state.open = false;
             }
         }
diff --git a/addons/web/static/tests/components/dropdown_menu_tests.js b/addons/web/static/tests/components/dropdown_menu_tests.js
index a0f00b68ef1..da0d458d680 100644
--- a/addons/web/static/tests/components/dropdown_menu_tests.js
+++ b/addons/web/static/tests/components/dropdown_menu_tests.js
@@ -339,5 +339,48 @@ odoo.define('web.dropdown_menu_tests', function (require) {
 
             parent.destroy();
         });
+
+        QUnit.test("dropdown doesn't get close on mousedown inside and mouseup outside dropdown", async function (assert) {
+            // In this test, we simulate a case where the user clicks inside a dropdown menu item
+            // (e.g. in the input of the 'Save current search' item in the Favorites menu), keeps
+            // the click pressed, moves the cursor outside the dropdown and releases the click
+            // (i.e. mousedown and focus inside the item, mouseup and click outside the dropdown).
+            // In this case, we want to keep the dropdown menu open.
+            assert.expect(5);
+
+            const items = this.items;
+            class Parent extends owl.Component {
+                constructor() {
+                    super(...arguments);
+                    this.items = items;
+                }
+            }
+            Parent.components = { DropdownMenu };
+            Parent.template = owl.tags.xml`
+                <div>
+                    <DropdownMenu class="first" title="'First'" items="items"/>
+                </div>`;
+            const parent = new Parent();
+            await parent.mount(testUtils.prepareTarget(), { position: "first-child" });
+
+            const menu = parent.el.querySelector(".o_dropdown");
+            assert.doesNotHaveClass(menu, "show", "dropdown should not be open");
+
+            await testUtils.dom.click(menu.querySelector("button"));
+            assert.hasClass(menu, "show", "dropdown should be open");
+
+            const firstItemEl = menu.querySelector(".o_menu_item > a");
+            // open options menu
+            await testUtils.dom.click(firstItemEl);
+            assert.hasClass(firstItemEl.querySelector("i"), "o_icon_right fa fa-caret-down");
+
+            // force the focus inside the dropdown item and click outside
+            firstItemEl.parentElement.querySelector(".o_menu_item_options .o_item_option a").focus();
+            await testUtils.dom.triggerEvents(parent.el, "click");
+            assert.hasClass(menu, "show", "dropdown should still be open");
+            assert.hasClass(firstItemEl.querySelector("i"), "o_icon_right fa fa-caret-down");
+
+            parent.destroy();
+        });
     });
 });