diff --git a/addons/web/static/src/core/tooltip/tooltip_service.js b/addons/web/static/src/core/tooltip/tooltip_service.js
index f4cf156bbc0..dea57c09cb5 100644
--- a/addons/web/static/src/core/tooltip/tooltip_service.js
+++ b/addons/web/static/src/core/tooltip/tooltip_service.js
@@ -104,14 +104,17 @@ export const tooltipService = {
             }
 
             openTooltipTimeout = browser.setTimeout(() => {
-                closeTooltip = popover.add(
-                    target,
-                    Tooltip,
-                    { tooltip, template, info },
-                    { position }
-                );
-                // Prevent title from showing on a parent at the same time
-                target.title = "";
+                // verify that the element is still in the DOM
+                if (target.isConnected) {
+                    closeTooltip = popover.add(
+                        target,
+                        Tooltip,
+                        { tooltip, template, info },
+                        { position }
+                    );
+                    // Prevent title from showing on a parent at the same time
+                    target.title = "";
+                }
             }, delay);
         }
 
diff --git a/addons/web/static/tests/core/tooltip/tooltip_service_tests.js b/addons/web/static/tests/core/tooltip/tooltip_service_tests.js
index e50cd584d04..54ab588edb4 100644
--- a/addons/web/static/tests/core/tooltip/tooltip_service_tests.js
+++ b/addons/web/static/tests/core/tooltip/tooltip_service_tests.js
@@ -424,4 +424,28 @@ QUnit.module("Tooltip service", (hooks) => {
         await triggerEvent(target, "button[data-tooltip]", "touchstart");
         assert.containsNone(target, ".o_popover_container .o_popover");
     });
+
+    QUnit.test("tooltip does not crash with disappearing target", async (assert) => {
+        class MyComponent extends Component {}
+        MyComponent.template = xml`<button class="mybtn" data-tooltip="hello">Action</button>`;
+        let simulateTimeout;
+        const mockSetTimeout = async (fn) => {
+            simulateTimeout = fn;
+        };
+        await makeParent(MyComponent, { mockSetTimeout });
+
+        assert.containsNone(target, ".o_popover_container .o_popover");
+        target.querySelector(".mybtn").dispatchEvent(new Event("mouseenter"));
+        await nextTick();
+        assert.containsNone(target, ".o_popover_container .o_popover");
+
+        // the element disappeared from the DOM during the setTimeout
+        target.querySelector(".mybtn").remove();
+
+        simulateTimeout();
+        await nextTick();
+
+        // tooltip did not crash and is not shown
+        assert.containsNone(target, ".o_popover_container .o_popover");
+    });
 });