diff --git a/addons/barcodes/static/src/barcode_service.js b/addons/barcodes/static/src/barcode_service.js
index f449c01a53e..0c1a2fb6e2b 100644
--- a/addons/barcodes/static/src/barcode_service.js
+++ b/addons/barcodes/static/src/barcode_service.js
@@ -28,6 +28,10 @@ export const barcodeService = {
     // this is done here to make it easily mockable in mobile tests
     isMobileChrome: isMobileOS() && isBrowserChrome(),
 
+    cleanBarcode: function(barcode) {
+        return barcode.replace(/Alt|Shift|Control/g, '');
+    },
+
     start() {
         const bus = new EventBus();
         let timeout = null;
@@ -47,7 +51,8 @@ export const barcodeService = {
          * check if we have a barcode, and trigger appropriate events
          */
         function checkBarcode() {
-            const str = barcodeInput ? barcodeInput.value : bufferedBarcode;
+            let str = barcodeInput ? barcodeInput.value : bufferedBarcode;
+            str = barcodeService.cleanBarcode(str);
             if (str.length >= 3) {
                 handleBarcode(str, currentTarget);
             }
@@ -66,9 +71,11 @@ export const barcodeService = {
                 return;
             }
             // Ignore 'Shift', 'Escape', 'Backspace', 'Insert', 'Delete', 'Home', 'End', Arrow*, F*, Page*, ...
-            // ctrl, meta and alt are often used for UX purpose (like shortcuts)
-            // Note: shiftKey is not ignored because it can be used by some barcode scanner for digits.
-            const isSpecialKey = ev.key.length > 1 || ev.ctrlKey || ev.metaKey || ev.altKey;
+            // meta is often used for UX purpose (like shortcuts)
+            // Notes:
+            // - shiftKey is not ignored because it can be used by some barcode scanner for digits.
+            // - altKey/ctrlKey are not ignored because it can be used in some barcodes (e.g. GS1 separator)
+            const isSpecialKey = !['Control', 'Alt'].includes(ev.key) && (ev.key.length > 1 || ev.metaKey);
             const isEndCharacter = ev.key.match(/(Enter|Tab)/);
 
             // Don't catch non-printable keys except 'enter' and 'tab'
diff --git a/addons/barcodes_gs1_nomenclature/__manifest__.py b/addons/barcodes_gs1_nomenclature/__manifest__.py
index 288b0111dca..671103a611a 100644
--- a/addons/barcodes_gs1_nomenclature/__manifest__.py
+++ b/addons/barcodes_gs1_nomenclature/__manifest__.py
@@ -14,6 +14,7 @@
     'assets': {
         'web.assets_backend': [
             'barcodes_gs1_nomenclature/static/src/js/barcode_parser.js',
+            'barcodes_gs1_nomenclature/static/src/js/barcode_service.js',
         ],
         'web.qunit_suite_tests': [
             'barcodes_gs1_nomenclature/static/src/js/tests/**/*',
diff --git a/addons/barcodes_gs1_nomenclature/models/__init__.py b/addons/barcodes_gs1_nomenclature/models/__init__.py
index 01218f2351b..d979a2928fc 100644
--- a/addons/barcodes_gs1_nomenclature/models/__init__.py
+++ b/addons/barcodes_gs1_nomenclature/models/__init__.py
@@ -1,2 +1,3 @@
 from . import barcode_nomenclature
 from . import barcode_rule
+from . import ir_http
diff --git a/addons/barcodes_gs1_nomenclature/models/barcode_nomenclature.py b/addons/barcodes_gs1_nomenclature/models/barcode_nomenclature.py
index b9a3df7d7ef..3ed7cec3ba1 100644
--- a/addons/barcodes_gs1_nomenclature/models/barcode_nomenclature.py
+++ b/addons/barcodes_gs1_nomenclature/models/barcode_nomenclature.py
@@ -16,8 +16,8 @@ class BarcodeNomenclature(models.Model):
         string="Is GS1 Nomenclature",
         help="This Nomenclature use the GS1 specification, only GS1-128 encoding rules is accepted is this kind of nomenclature.")
     gs1_separator_fnc1 = fields.Char(
-        string="FNC1 Separator", trim=False,
-        help="Alternative regex delimiter for the FNC1 (by default, if not set, it is <GS> ASCII 29 char). The separator must not match the begin/end of any related rules pattern.")
+        string="FNC1 Separator", trim=False, default=r'(Alt029|#|\x1D)',
+        help="Alternative regex delimiter for the FNC1. The separator must not match the begin/end of any related rules pattern.")
 
     @api.constrains('gs1_separator_fnc1')
     def _check_pattern(self):
diff --git a/addons/barcodes_gs1_nomenclature/models/ir_http.py b/addons/barcodes_gs1_nomenclature/models/ir_http.py
new file mode 100644
index 00000000000..58b95bfefdc
--- /dev/null
+++ b/addons/barcodes_gs1_nomenclature/models/ir_http.py
@@ -0,0 +1,16 @@
+# -*- coding: utf-8 -*-
+# Part of Odoo. See LICENSE file for full copyright and licensing details.
+
+from odoo import models
+
+
+class IrHttp(models.AbstractModel):
+    _inherit = 'ir.http'
+
+    def session_info(self):
+        res = super().session_info()
+        nomenclature = self.env.company.nomenclature_id
+        if not nomenclature.is_gs1_nomenclature:
+            return res
+        res['gs1_group_separator_encodings'] = nomenclature.gs1_separator_fnc1
+        return res
diff --git a/addons/barcodes_gs1_nomenclature/static/src/js/barcode_parser.js b/addons/barcodes_gs1_nomenclature/static/src/js/barcode_parser.js
index 1de5b782326..f17e14e5881 100644
--- a/addons/barcodes_gs1_nomenclature/static/src/js/barcode_parser.js
+++ b/addons/barcodes_gs1_nomenclature/static/src/js/barcode_parser.js
@@ -88,9 +88,6 @@ BarcodeParser.include({
         const results = [];
         const rules = this.nomenclature.rules.filter(rule => rule.encoding === 'gs1-128');
         let separatorReg = FNC1_CHAR + "?";
-        if (this.nomenclature.gs1_separator_fnc1 && this.nomenclature.gs1_separator_fnc1.trim()){
-            separatorReg = `(?:${this.nomenclature.gs1_separator_fnc1})?`;
-        }
 
         while (barcode.length > 0) {
             const barcodeLength = barcode.length;
@@ -151,5 +148,8 @@ BarcodeParser.include({
     },
 });
 
-return BarcodeParser;
+return {
+    BarcodeParser,
+    FNC1_CHAR,
+};
 });
diff --git a/addons/barcodes_gs1_nomenclature/static/src/js/barcode_service.js b/addons/barcodes_gs1_nomenclature/static/src/js/barcode_service.js
new file mode 100644
index 00000000000..d37a4adb811
--- /dev/null
+++ b/addons/barcodes_gs1_nomenclature/static/src/js/barcode_service.js
@@ -0,0 +1,18 @@
+/** @odoo-module **/
+
+import { session } from "@web/session";
+import { patch } from "@web/core/utils/patch";
+import { barcodeService } from '@barcodes/barcode_service';
+
+import { FNC1_CHAR } from "barcodes_gs1_nomenclature/static/src/js/barcode_parser.js";
+
+
+patch(barcodeService, 'barcodes_gs1_nomenclature', {
+    // Use the regex given by the session, else use an impossible one
+    gs1SeparatorRegex: new RegExp(session.gs1_group_separator_encodings || '.^', 'g'),
+
+    cleanBarcode: function(barcode) {
+        barcode = barcode.replace(barcodeService.gs1SeparatorRegex, FNC1_CHAR);
+        return this._super(barcode);
+    },
+});
diff --git a/addons/barcodes_gs1_nomenclature/static/src/js/tests/barcode_parser_tests.js b/addons/barcodes_gs1_nomenclature/static/src/js/tests/barcode_parser_tests.js
index 5da8f68be94..c5cca71ff7b 100644
--- a/addons/barcodes_gs1_nomenclature/static/src/js/tests/barcode_parser_tests.js
+++ b/addons/barcodes_gs1_nomenclature/static/src/js/tests/barcode_parser_tests.js
@@ -248,35 +248,6 @@ QUnit.module('Barcode GS1 Parser', {
 
     });
 
-    QUnit.test('Test Alternative GS1 Separator (fnc1)', async function (assert) {
-        assert.expect(6);
-        let barcodeNomenclature = new BarcodeParser({'nomenclature_id': 2});
-        await barcodeNomenclature.loaded;
-
-        barcodeNomenclature.nomenclature = this.data['barcode.nomenclature'].records[0];
-        barcodeNomenclature.nomenclature.gs1_separator_fnc1 = "#";
-        barcodeNomenclature.nomenclature.rules = this.data['barcode.rule'].records;
-
-        // (21)12345(15)090101(16)100101
-        let code128 = "2112345\x1D1509010116100101";
-        let res;
-        try {
-            res = barcodeNomenclature.gs1_decompose_extanded(code128);
-        } catch (error) {
-            assert.ok(
-                error instanceof Error,
-                "Default separator shouldn't work"
-            );
-        }
-
-        code128 = "2112345#1509010116100101";
-        res = barcodeNomenclature.gs1_decompose_extanded(code128);
-        assert.equal(res.length, 3);
-        assert.equal(res[0].ai, "21");
-        assert.equal(res[0].value, "12345");
-        assert.equal(res[1].ai, "15");
-        assert.equal(res[2].ai, "16");
-    });
 });
 });
 });