diff --git a/addons/mail/static/src/core/common/user_settings_service.js b/addons/mail/static/src/core/common/user_settings_service.js
index eb32b744220..84e898584af 100644
--- a/addons/mail/static/src/core/common/user_settings_service.js
+++ b/addons/mail/static/src/core/common/user_settings_service.js
@@ -108,9 +108,13 @@ export class UserSettings {
      * @param {event} ev
      */
     async setPushToTalkKey(ev) {
-        const pushToTalkKey = `${ev.shiftKey || ""}.${ev.ctrlKey || ev.metaKey || ""}.${
+        const nonElligibleKeys = new Set(["Shift", "Control", "Alt", "Meta"]);
+        let pushToTalkKey = `${ev.shiftKey || ""}.${ev.ctrlKey || ev.metaKey || ""}.${
             ev.altKey || ""
-        }.${ev.key === " " ? "Space" : ev.key}`;
+        }`;
+        if (!nonElligibleKeys.has(ev.key)) {
+            pushToTalkKey += `.${ev.key === " " ? "Space" : ev.key}`;
+        }
         this.pushToTalkKey = pushToTalkKey;
         this._saveSettings();
     }
@@ -149,25 +153,43 @@ export class UserSettings {
 
     // methods
 
+    buildKeySet({ shiftKey, ctrlKey, altKey, key }) {
+        const keys = new Set();
+        if (key) {
+            keys.add(key === "Meta" ? "Alt" : key);
+        }
+        if (shiftKey) {
+            keys.add("Shift");
+        }
+        if (ctrlKey) {
+            keys.add("Control");
+        }
+        if (altKey) {
+            keys.add("Alt");
+        }
+        return keys;
+    }
+
     /**
      * @param {event} ev
      * @param {Object} param1
-     * @param {boolean} param1.ignoreModifiers
      */
-    isPushToTalkKey(ev, { ignoreModifiers = false } = {}) {
+    isPushToTalkKey(ev) {
         if (!this.usePushToTalk || !this.pushToTalkKey) {
             return false;
         }
-        const { key, shiftKey, ctrlKey, altKey } = this.pushToTalkKeyFormat();
-        if (ignoreModifiers) {
-            return ev.key === key;
+        const [shiftKey, ctrlKey, altKey, key] = this.pushToTalkKey.split(".");
+        const settingsKeySet = this.buildKeySet({ shiftKey, ctrlKey, altKey, key });
+        const eventKeySet = this.buildKeySet({
+            shiftKey: ev.shiftKey,
+            ctrlKey: ev.ctrlKey,
+            altKey: ev.altKey,
+            key: ev.key,
+        });
+        if (ev.type === "keydown") {
+            return [...settingsKeySet].every((key) => eventKeySet.has(key));
         }
-        return (
-            ev.key === key &&
-            ev.shiftKey === shiftKey &&
-            ev.ctrlKey === ctrlKey &&
-            ev.altKey === altKey
-        );
+        return settingsKeySet.has(ev.key === "Meta" ? "Alt" : ev.key);
     }
     pushToTalkKeyFormat() {
         if (!this.pushToTalkKey) {
diff --git a/addons/mail/static/src/discuss/call/common/call_settings.js b/addons/mail/static/src/discuss/call/common/call_settings.js
index a771daaf14a..42e2e98830f 100644
--- a/addons/mail/static/src/discuss/call/common/call_settings.js
+++ b/addons/mail/static/src/discuss/call/common/call_settings.js
@@ -39,7 +39,10 @@ export class CallSettings extends Component {
     get pushToTalkKeyText() {
         const { shiftKey, ctrlKey, altKey, key } = this.userSettings.pushToTalkKeyFormat();
         const f = (k, name) => (k ? name : "");
-        return `${f(ctrlKey, "Ctrl + ")}${f(altKey, "Alt + ")}${f(shiftKey, "Shift + ")}${key}`;
+        const keys = [f(ctrlKey, "Ctrl"), f(altKey, "Alt"), f(shiftKey, "Shift"), key].filter(
+            Boolean
+        );
+        return keys.join(" + ");
     }
 
     _onKeyDown(ev) {
diff --git a/addons/mail/static/src/discuss/call/common/rtc_service.js b/addons/mail/static/src/discuss/call/common/rtc_service.js
index 7671220dfb0..ed403f4e799 100644
--- a/addons/mail/static/src/discuss/call/common/rtc_service.js
+++ b/addons/mail/static/src/discuss/call/common/rtc_service.js
@@ -214,7 +214,7 @@ export class Rtc {
                 if (
                     !this.state.channel ||
                     !this.userSettingsService.usePushToTalk ||
-                    !this.userSettingsService.isPushToTalkKey(ev, { ignoreModifiers: true }) ||
+                    !this.userSettingsService.isPushToTalkKey(ev) ||
                     !this.state.selfSession.isTalking
                 ) {
                     return;