diff --git a/addons/web_editor/static/src/js/backend/html_field.js b/addons/web_editor/static/src/js/backend/html_field.js
index 477d5bd6786..8ba88b1e815 100644
--- a/addons/web_editor/static/src/js/backend/html_field.js
+++ b/addons/web_editor/static/src/js/backend/html_field.js
@@ -575,6 +575,7 @@ export class HtmlField extends Component {
      */
     async _toInline() {
         const $editable = this.wysiwyg.getEditable();
+        this.wysiwyg.odooEditor.sanitize(this.wysiwyg.odooEditor.editable);
         const html = this.wysiwyg.getValue();
         const $odooEditor = $editable.closest('.odoo-editor-editable');
         // Save correct nodes references.
diff --git a/addons/web_editor/static/src/js/editor/odoo-editor/src/utils/sanitize.js b/addons/web_editor/static/src/js/editor/odoo-editor/src/utils/sanitize.js
index 20f09f5c1d2..359cb18c9c6 100644
--- a/addons/web_editor/static/src/js/editor/odoo-editor/src/utils/sanitize.js
+++ b/addons/web_editor/static/src/js/editor/odoo-editor/src/utils/sanitize.js
@@ -149,6 +149,11 @@ class Sanitize {
                 node = nodeP;
             }
 
+            // Remove comment nodes to avoid issues with mso comments.
+            if (node.nodeType === Node.COMMENT_NODE) {
+                node.remove();
+            }
+
             const selection = this.root.ownerDocument.getSelection();
             const anchor = selection && selection.anchorNode;
             const anchorEl = anchor && closestElement(anchor);
diff --git a/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/editor.test.js b/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/editor.test.js
index bf1213690f9..c17c3a37480 100644
--- a/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/editor.test.js
+++ b/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/editor.test.js
@@ -5778,6 +5778,15 @@ X[]
         });
     });
 
+    describe('comment node', () => {
+        it('should remove comment node inside editable content during sanitize', async () => {
+            await testEditor(BasicEditor, {
+                contentBefore: '<p>ab<!-- comment -->cd</p>',
+                contentAfter: '<p>abcd</p>',
+            });
+        });
+    });
+
     describe('markdown', () => {
         describe('inline code', () => {
             it('should convert text into inline code (start)', async () => {