diff --git a/addons/payment_mercado_pago/models/payment_transaction.py b/addons/payment_mercado_pago/models/payment_transaction.py
index 847e1fbb94c..5d6fd9e22f7 100644
--- a/addons/payment_mercado_pago/models/payment_transaction.py
+++ b/addons/payment_mercado_pago/models/payment_transaction.py
@@ -2,6 +2,7 @@
 
 import logging
 import pprint
+from urllib.parse import quote as url_quote
 
 from werkzeug import urls
 
@@ -58,8 +59,9 @@ class PaymentTransaction(models.Model):
         """
         base_url = self.provider_id.get_base_url()
         return_url = urls.url_join(base_url, MercadoPagoController._return_url)
+        sanitized_reference = url_quote(self.reference)
         webhook_url = urls.url_join(
-            base_url, f'{MercadoPagoController._webhook_url}/{self.reference}'
+            base_url, f'{MercadoPagoController._webhook_url}/{sanitized_reference}'
         )  # Append the reference to identify the transaction from the webhook notification data.
 
         # In the case where we are issuing a preference request in CLP or COP, we must ensure that
diff --git a/addons/payment_mercado_pago/tests/test_payment_transaction.py b/addons/payment_mercado_pago/tests/test_payment_transaction.py
index 28e40935413..a92649d4443 100644
--- a/addons/payment_mercado_pago/tests/test_payment_transaction.py
+++ b/addons/payment_mercado_pago/tests/test_payment_transaction.py
@@ -1,6 +1,7 @@
 # Part of Odoo. See LICENSE file for full copyright and licensing details.
 
 from unittest.mock import patch
+from urllib.parse import quote as url_quote
 
 from odoo.tests import tagged
 from odoo.tools import mute_logger
@@ -19,6 +20,7 @@ class TestPaymentTransaction(MercadoPagoCommon, PaymentHttpCommon):
         self.maxDiff = 10000  # Allow comparing large dicts.
         return_url = self._build_url('/payment/mercado_pago/return')
         webhook_url = self._build_url('/payment/mercado_pago/webhook')
+        sanitized_reference = url_quote(tx.reference)
         self.assertDictEqual(request_payload, {
             'auto_return': 'all',
             'back_urls': {
@@ -33,7 +35,7 @@ class TestPaymentTransaction(MercadoPagoCommon, PaymentHttpCommon):
                 'title': tx.reference,
                 'unit_price': tx.amount,
             }],
-            'notification_url': f'{webhook_url}/{tx.reference}',
+            'notification_url': f'{webhook_url}/{sanitized_reference}',
             'payer': {
                 'address': {'street_name': tx.partner_address, 'zip_code': tx.partner_zip},
                 'email': tx.partner_email,