diff --git a/addons/web_editor/static/src/js/editor/odoo-editor/src/powerbox/Powerbox.js b/addons/web_editor/static/src/js/editor/odoo-editor/src/powerbox/Powerbox.js
index cbe380066d2..a19c2dc0265 100644
--- a/addons/web_editor/static/src/js/editor/odoo-editor/src/powerbox/Powerbox.js
+++ b/addons/web_editor/static/src/js/editor/odoo-editor/src/powerbox/Powerbox.js
@@ -333,7 +333,12 @@ export class Powerbox {
                 true,
             );
             this._context.lastText = diff.bMove.join('');
-            if (this._context.lastText.match(/\s/)) {
+            const selection = this.document.getSelection();
+            if (
+                this._context.lastText.match(/\s/) ||
+                !selection ||
+                this._context.initialTarget !== closestBlock(selection.anchorNode)
+            ) {
                 this.close();
             } else {
                 const term = this._context.lastText.toLowerCase()
diff --git a/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/powerbox.test.js b/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/powerbox.test.js
index 3f08a7c1a8b..4bfad7028ad 100644
--- a/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/powerbox.test.js
+++ b/addons/web_editor/static/src/js/editor/odoo-editor/test/spec/powerbox.test.js
@@ -66,6 +66,18 @@ describe('Powerbox', () => {
                 contentAfter: '<h1>ab[]</h1>',
             });
         });
+        it('should close the powerbox if keyup event is called on other block', async () => {
+            await testEditor(BasicEditor, {
+                contentBefore: '<p>ab</p><p>c[]d</p>',
+                stepFunction: async (editor) => {
+                    await insertText(editor, '/');
+                    window.chai.expect(editor.powerbox.isOpen).to.be.true;
+                    setSelection(editor.editable.firstChild, 1);
+                    await triggerEvent(editor.editable, 'keyup');
+                    window.chai.expect(editor.powerbox.isOpen).to.be.false;
+                },
+            });
+        });
     });
     it('should insert a 3x3 table on type `/table` in mobile view', async () => {
         if(_isMobile()){